Description

Protac Mdm2 Degrader-3 is a potent and selective small molecule degrader designed for targeted protein degradation research. This compound functions as a PROTAC (PROteolysis TArgeting Chimera), specifically engineered to induce the ubiquitination and subsequent proteasomal degradation of the MDM2 oncoprotein. It is an essential research tool for scientists in oncology, chemical biology, and drug discovery, enabling the study of MDM2 function and the validation of novel therapeutic strategies in cancer research.

Application

• Chemical Biology Research: A key reagent for studying PROTAC technology, ubiquitin-proteasome system (UPS) dynamics, and targeted protein degradation mechanisms.
• Oncology & Cancer Research: Used to investigate the role of MDM2 in tumorigenesis, p53 pathway regulation, and to evaluate degradation as a potential anti-cancer therapeutic approach.
• Drug Discovery & Preclinical Development: Serves as a critical tool compound for hit-to-lead optimization, proof-of-concept studies, and the development of novel MDM2-targeting degrader therapeutics.
• Academic & Pharmaceutical R&D: Employed in high-throughput screening (HTS) assays, cellular phenotype studies, and mechanistic investigations to understand protein function and drug resistance.
• Biomarker & Target Validation: Facilitates the validation of MDM2 as a therapeutic target in various cancer cell lines and disease models.

Basic Information

Product Name	Protac Mdm2 Degrader-3
CAS No.	2249750-23-8
Molecular Formula	C₄₇H₅₀ClN₉O₇S
Molecular Weight	920.46 g/mol
Synonyms	PROTAC MDM2 Degrader-3; MD-224; (S,R,S)-AHPC-MDM2 Ligand-Linker Conjugate 3; VHL Ligand-Linker Conjugates 12; (S,R,S)-AHPC-C6-NH-C5-piperazine-C2-amide-C6-amide-C2-Cl; Degrader of MDM2; MDM2-PROTAC 3; PROTAC-based MDM2 Degrader
EINECS	Contact for details

Quality Control

Our Protac Mdm2 Degrader-3 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and is supplied with a comprehensive Certificate of Analysis (COA). We adhere to high standards suitable for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.