Description

Aak1 Inhibitor 1 CAS NO 2247894-32-0 is a potent and selective small molecule inhibitor of the Apoptosis-associated kinase 1 (Aak1), a key regulator of clathrin-mediated endocytosis. This compound is a critical research tool for investigating cellular trafficking pathways and their implications in neurological disorders and other disease states. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in target validation, mechanism-of-action studies, and preclinical drug discovery.

Application

• Neurological Research: Investigation of Aak1's role in synaptic vesicle recycling and its connection to neurodegenerative diseases.
• Cellular Biology Studies: Tool compound for probing clathrin-mediated endocytosis and intracellular trafficking mechanisms in vitro.
• Drug Discovery & Target Validation: Used in high-throughput screening (HTS) and hit-to-lead optimization campaigns targeting Aak1.
• Preclinical Pharmacology: Evaluation of therapeutic potential in animal models of relevant neurological conditions.
• Biochemical Assay Development: Serves as a reference standard in kinase inhibition assays and enzymatic studies.

Basic Information

Product Name	Aak1 Inhibitor 1
CAS No.	2247894-32-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Aak1 Inhibitor; Apoptosis-associated kinase 1 Inhibitor; AAK1 Inhibitor; 2247894-32-0; Aak1 kinase inhibitor; BMP-2-inducible kinase inhibitor; BIKE inhibitor
EINECS	Contact for details

Quality Control

Our Aak1 Inhibitor 1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation, to ensure identity, potency, and consistency for research use. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.