Description

(4-Chloro-1-Methyl-1H-Pyrazol-3-Yl)Methanesulfonyl Chloride CAS NO 2245066-84-4 is a high-purity, reactive sulfonyl chloride derivative of a chlorinated pyrazole, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, enabling the introduction of both a chloropyrazole moiety and a versatile methanesulfonyl chloride group for further derivatization. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for constructing novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting various disease pathways.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactive pyrazole core.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and the development of activity-based probes due to its sulfonyl chloride group.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialized polymers with unique properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.
• Academic & R&D Laboratories: Employed in methodological research and the discovery of new chemical reactions and catalytic processes.

Basic Information

Item	Details
Product Name	(4-Chloro-1-Methyl-1H-Pyrazol-3-Yl)Methanesulfonyl Chloride
CAS No.	2245066-84-4
Molecular Formula	C6H8Cl2N2O2S
Molecular Weight	243.11 g/mol
Synonyms	4-Chloro-1-methyl-1H-pyrazole-3-methanesulfonyl chloride; (4-Chloro-1-methyl-1H-pyrazol-3-yl)methanesulfonyl chloride; 3-(Chlorosulfonylmethyl)-4-chloro-1-methyl-1H-pyrazole; 4-Chloro-1-methyl-3-(chlorosulfonylmethyl)pyrazole; Pyrazole-3-methanesulfonyl chloride, 4-chloro-1-methyl-; CAS 2245066-84-4
EINECS	Contact for details

Quality Control

Our production of (4-Chloro-1-Methyl-1H-Pyrazol-3-Yl)Methanesulfonyl Chloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure consistency and reliability. Certificates of Analysis (COA) documenting all critical parameters are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases, oxidizers, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.