Description

Homo-Protac Pvhl30 Degrader 1 is a potent and selective bifunctional degrader molecule designed for targeted protein degradation research. This compound is a critical tool for advancing the study of the von Hippel-Lindau (VHL) E3 ligase pathway and PROTAC (PROteolysis TArgeting Chimera) technology. It is essential for pharmaceutical R&D, biotechnology, and academic laboratories focused on novel therapeutic modalities, drug discovery, and chemical biology. The product is supplied with a CAS number of 2244684-49-7.

Application

• PROTAC & Targeted Protein Degradation (TPD) Research: Serves as a key chemical probe to validate and study PROTAC-mediated degradation mechanisms.
• VHL E3 Ligase Pathway Investigation: Used to explore the function and substrate recruitment of the VHL ubiquitin ligase complex.
• Oncology Drug Discovery: Facilitates the development of novel cancer therapies by enabling the targeted degradation of disease-relevant proteins.
• Chemical Biology Tool: Employed in cellular and biochemical assays to understand protein function and signaling pathways.
• Hit-to-Lead Optimization: Provides a structural scaffold for medicinal chemistry programs aimed at improving degrader potency, selectivity, and drug-like properties.
• Academic Research: Supports fundamental research in ubiquitin-proteasome system (UPS) biology and novel therapeutic strategies.

Basic Information

Product Name	Homo-Protac Pvhl30 Degrader 1
CAS No.	2244684-49-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC VHL Degrader 1; Homo-PROTAC Pvhl30 Degrader; VHL-based Homo-PROTAC; VHL Recruiting Molecule 1; Bifunctional VHL Degrader; VHL Ligand-Linker Conjugate; Targeted Protein Degrader for VHL; (2S,4R)-1-((S)-2-(2-(2-(2-(2-(2-(2-(4-(4-(((S)-4-Methyl-2-((S)-3-methylbutanamido)pentanamido)methyl)benzamido)butanamido)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)acetyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
EINECS	Contact for details

Quality Control

Our high-purity research chemicals undergo rigorous analytical testing to ensure identity, purity, and batch-to-batch consistency, meeting the stringent requirements of pharmaceutical R&D. Quality is verified by advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every batch to support your research and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.