Description

Homo-Protac Cereblon Degrader 1 CAS NO 2244520-98-5 is a potent and selective bifunctional degrader molecule designed for targeted protein degradation (TPD) research. This compound is engineered to recruit the E3 ubiquitin ligase Cereblon to a protein of interest, inducing its ubiquitination and subsequent proteasomal degradation. It serves as a critical research tool for scientists in pharmaceutical R&D and academic institutions exploring novel therapeutic modalities for oncology, neurodegenerative diseases, and other challenging targets.

Application

• Targeted Protein Degradation (TPD) Research: A core tool for developing and validating PROTAC (Proteolysis Targeting Chimera) molecules in cellular and biochemical assays.
• Oncology Drug Discovery: Used to study the degradation of oncogenic proteins and validate new targets for cancer therapy.
• Mechanistic Biology Studies: Enables investigation of protein function and signaling pathways by inducing selective protein knockdown.
• Neurological Disease Research: Applied in models to explore the degradation of pathogenic proteins associated with neurodegenerative conditions.
• Chemical Biology Probe Development: Serves as a starting point or benchmark compound for creating novel bifunctional degraders.
• Preclinical Proof-of-Concept Studies: Utilized in in vitro and in vivo models to assess the efficacy and feasibility of degradation-based therapeutic strategies.

Basic Information

Product Name	Homo-Protac Cereblon Degrader 1
CAS No.	2244520-98-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cereblon Degrader 1; Homo-PROTAC 1; CRBN Recruiter 1; Bifunctional Cereblon Ligand 1; PROTAC Molecule for Cereblon; Targeted Protein Degrader 1; E3 Ligase Recruiter; (Chemical name details available on request)
EINECS	Contact for details

Quality Control

Our Homo-Protac Cereblon Degrader 1 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for reliable research outcomes. Each lot is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry characterization. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.