Description

Jak1-In-7 is a potent and selective small-molecule inhibitor of the Janus kinase 1 (JAK1) enzyme. This compound is a critical research tool for investigating JAK-STAT signaling pathways, which are implicated in a wide range of autoimmune, inflammatory, and oncological processes. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on immunology and oncology drug discovery.

Application

• Biomedical Research: A key reagent for studying the role of JAK1 in cellular signaling, immune response modulation, and disease pathology.
• Drug Discovery & Development: Serves as a reference compound or a lead structure in high-throughput screening and hit-to-lead optimization campaigns for novel JAK inhibitors.
• Mechanistic Studies: Used to elucidate the specific contributions of JAK1 versus other JAK family members (JAK2, JAK3, TYK2) in experimental models.
• Preclinical Validation: Employed in in vitro and in vivo studies to validate JAK1 as a therapeutic target for conditions like rheumatoid arthritis, psoriasis, and certain cancers.
• Biochemical Assay Development: Acts as a control inhibitor in enzymatic and cell-based assays to test the potency and selectivity of new chemical entities.

Basic Information

Product Name	Jak1-In-7
CAS No.	2241039-81-4
Molecular Formula	C₂₄H₂₅N₅O₂
Molecular Weight	415.49 g/mol
Synonyms	JAK1-IN-7; (S)-N-(4-(1-Acryloylpiperidin-3-yl)-2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)phenyl)-2-methylpropane-2-sulfinamide; JAK1 Inhibitor-7; 2241039-81-4; JAK1 inhibitor compound 7; (S)-tert-Butylsulfinyl JAK1 inhibitor.
EINECS	Contact for details

Quality Control

Our Jak1-In-7 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and quality specifications is provided with every shipment to ensure reproducibility and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.