Description

Nampt Inhibitor-Linker 1 is a specialized bifunctional chemical entity designed for the development of targeted therapeutic conjugates. This compound is critical for researchers and developers creating novel Antibody-Drug Conjugates (ADCs) and other targeted therapies that inhibit Nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in the NAD+ salvage pathway. It is essential for pharmaceutical R&D, biotechnology companies, and academic institutions focused on oncology and metabolic disease research, where precise drug targeting is paramount.

Application

• ADC (Antibody-Drug Conjugate) Payload-Linker Construction: Serves as a critical component for attaching potent NAMPT inhibitor warheads to targeting antibodies or other biologics.
• Targeted Cancer Therapy Development: Enables the creation of therapeutics designed to selectively deliver NAMPT inhibition to tumor cells, minimizing off-target effects.
• Proteolysis-Targeting Chimera (PROTAC) & Molecular Glue Design: Used as a linker moiety in bifunctional molecules aimed at degrading target proteins via the ubiquitin-proteasome system.
• Chemical Biology Research: A valuable tool for studying the NAMPT pathway and its role in cellular metabolism, cancer proliferation, and aging.
• Precision Medicine Platforms: Integral to developing next-generation therapies that combine specific enzyme inhibition with targeted delivery mechanisms.
• High-Throughput Screening (HTS) Libraries: Included in specialized compound libraries for discovering new targeted inhibitor conjugates.

Basic Information

Product Name	Nampt Inhibitor-Linker 1
CAS No.	2241019-57-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	NAMPT Inhibitor-Linker Conjugate 1; ADC Linker for NAMPT Inhibitor; Bifunctional NAMPT Targeting Agent; NAMPTi-Linker 1; Targeted NAMPT Inhibitor Construct; CAS 2241019-57-6; Anti-NAMPT ADC Intermediate
EINECS	Contact for details

Quality Control

Our Nampt Inhibitor-Linker 1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D applications. All materials are supported by comprehensive analytical data. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.