Description

Nampt Inhibitor-Linker 2 is a specialized bifunctional chemical entity designed for the development of targeted therapeutic conjugates. This compound is critical for researchers and pharmaceutical developers seeking to create novel Antibody-Drug Conjugates (ADCs) and other targeted delivery systems by inhibiting Nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in the NAD+ salvage pathway. It is primarily utilized in advanced oncology research and preclinical drug development by biopharmaceutical companies and academic institutions focused on next-generation cancer therapies.

Application

• Antibody-Drug Conjugate (ADC) Payload-Linker Construction: Serves as a critical component for synthesizing ADCs, connecting cytotoxic warheads to targeting antibodies.
• Targeted Cancer Therapy Research: Used in the development of prodrugs and targeted delivery systems that exploit the NAMPT inhibition mechanism.
• Chemical Biology & Probe Development: Acts as a key reagent for creating activity-based probes to study NAD+ metabolism and NAMPT function in cellular models.
• Preclinical Pharmaceutical Development: Employed in lead optimization and proof-of-concept studies for novel oncology candidates.
• Proteolysis-Targeting Chimera (PROTAC) Design: Can be utilized as a ligand in the design of heterobifunctional molecules aimed at degrading target proteins.
• High-Throughput Screening (HTS): Serves as a reference compound or building block in screening libraries for drug discovery campaigns.

Basic Information

Product Name	Nampt Inhibitor-Linker 2
CAS No.	2241014-82-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	NAMPT Inhibitor-Linker 2; Linker for NAMPT inhibitor-based ADCs; ADC linker-payload for NAMPT inhibition; NAMPTi-Linker 2; Chemical conjugate for NAMPT targeting; Bifunctional NAMPT inhibitor linker; (S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-6-((2-(5-((4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)butyl)carbamoyl)pyridin-2-yl)ethyl)amino)-6-oxohexanoic acid (IUPAC)
EINECS	Contact for details

Quality Control

Every batch of Nampt Inhibitor-Linker 2 is produced and analyzed under strict quality management protocols to ensure consistency and reliability for critical research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for identity, purity, and related substances as determined by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.