Description

Ehmt2-In-2 is a potent and selective small-molecule inhibitor of the histone methyltransferase EHMT2 (also known as G9a). This compound is a critical research tool for the study of epigenetic regulation, specifically targeting histone H3 lysine 9 (H3K9) methylation. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology, neurology, and epigenetics discovery programs. The high specificity of Ehmt2-In-2 makes it invaluable for validating EHMT2 as a therapeutic target and for probing disease mechanisms.

Application

• Epigenetics Research: A key reagent for studying the role of H3K9 methylation in gene silencing, heterochromatin formation, and cellular differentiation.
• Oncology Drug Discovery: Used in target validation and screening assays to evaluate EHMT2 inhibition as a potential therapeutic strategy for various cancers.
• Neuroscience Studies: Applied in research models to investigate the link between EHMT2 activity and neurological disorders, including cognitive function and neurodevelopment.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening (HTS) and enzymatic activity assays.
• Cell Biology & Functional Genomics: Enables researchers to dissect specific epigenetic pathways and their phenotypic consequences in cell culture models.
• Preclinical Proof-of-Concept Studies: Supports in vitro and in vivo studies to establish the pharmacological profile of EHMT2 inhibition.

Basic Information

Product Name	Ehmt2-In-2
CAS No.	2230850-47-0
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	EHMT2-IN-2; G9a Inhibitor; UNC0638 analog; Histone Methyltransferase G9a Inhibitor; G9a/EHMT2 Inhibitor; 1-[(2S,4R)-1-Acetyl-4-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-2-pyrrolidinyl]-3-(4-fluorophenyl)urea; BIX-01294 derivative; Epigenetic inhibitor
EINECS	Contact for details

Quality Control

Our Ehmt2-In-2 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and strength. We support research compliance with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.