Description

Ehmt2-In-1 CAS NO 2230849-55-3 is a potent, small-molecule inhibitor targeting the histone methyltransferase EHMT2 (also known as G9a). This compound matters for researchers as it provides a critical tool for modulating epigenetic pathways, specifically histone H3 lysine 9 (H3K9) methylation, which is implicated in gene silencing and cellular differentiation. It is primarily needed by pharmaceutical R&D teams and academic laboratories focused on oncology, neurology, and the development of novel epigenetic therapies.

Application

• Epigenetics Research: A key chemical probe for studying the biological functions and mechanisms of the EHMT2/G9a methyltransferase in cellular models.
• Oncology Drug Discovery: Used in target validation and screening assays to develop novel therapeutics for cancers where EHMT2 overexpression plays a role.
• Neuroscience Studies: Applied in research investigating the role of histone methylation in neurological disorders, neurodevelopment, and synaptic plasticity.
• Biochemical Assay Development: Serves as a reference standard and active control in high-throughput screening (HTS) and in vitro enzyme inhibition assays.
• Stem Cell & Differentiation Research: Utilized to manipulate epigenetic marks to control stem cell fate and understand cellular reprogramming.
• Inhibitor Structure-Activity Relationship (SAR) Studies: Provides a core scaffold for medicinal chemistry efforts to design more potent or selective EHMT2 inhibitors.

Basic Information

Product Name	Ehmt2-In-1
CAS No.	2230849-55-3
Molecular Formula	C₂₀H₂₃N₅O₂
Molecular Weight	365.43 g/mol
Synonyms	EHMT2-IN-1; G9a Inhibitor; UNC0638 analog; Histone Methyltransferase G9a Inhibitor; (S)-1-(5-(4-Fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-3-yl)-N-(1-(2-(pyrrolidin-1-yl)acetyl)piperidin-3-yl)methanesulfonamide; GLP Inhibitor; Lysine Methyltransferase Inhibitor
EINECS	Contact for details

Quality Control

Our Ehmt2-In-1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and NMR for structural verification, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available upon request for traceability and assurance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container must be sealed under dry conditions and allowed to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.