Description

Foretinib-Based Protac 7 is a potent and selective bifunctional degrader molecule designed for targeted protein degradation research. This compound is engineered to hijack the cell's natural ubiquitin-proteasome system to induce the selective degradation of specific target proteins, offering a powerful tool for probing protein function and validating novel therapeutic targets. It is primarily utilized by pharmaceutical R&D teams, academic research laboratories, and biotechnology companies focused on oncology, neurodegenerative diseases, and innovative drug discovery platforms.

Application

• Chemical Biology Research: A critical tool for studying protein function, signaling pathways, and cellular processes via targeted protein degradation.
• Drug Discovery & Target Validation: Used in preclinical research to validate novel drug targets by assessing phenotypic consequences of target protein removal.
• Oncology Research: Investigation of cancer cell dependencies and the development of potential therapeutic strategies against specific oncoproteins.
• PROTAC Platform Development: Serves as a reference compound or a starting point for the design and optimization of new Proteolysis Targeting Chimeras (PROTACs).
• Mechanistic Studies: Elucidation of degradation kinetics, ternary complex formation, and ubiquitin ligase engagement for specific target proteins.

Basic Information

Product Name	Foretinib-Based Protac 7
CAS No.	2230821-68-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Foretinib-based 7; Foretinib-PROTAC 7; Degrader based on Foretinib; (S)-N-((S)-1-((S)-4-Methyl-2-((2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)amino)pentanoyl)pyrrolidine-2-carbonyl)-2-((6-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyridin-3-yl)methyl)isoindoline-5-carboxamide; Bifunctional Foretinib Degrader; Targeted Protein Degrader 7; TPD-7 (Foretinib)
EINECS	Contact for details

Quality Control

Our Foretinib-Based Protac 7 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are available upon request to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers should be sealed under dry, inert gas (e.g., argon or nitrogen) and allowed to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.