Description

(S)-1-(5-Bromopyridin-3-Yl)-2,2,2-Trifluoroethanol is a high-value, chiral trifluoromethylated building block of significant interest in modern synthetic chemistry. Its core value lies in the combination of a bromopyridine moiety, a chiral center, and the trifluoroethanol group, which is prized for its ability to modulate the physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the synthesis of advanced crop protection agents, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty chemicals and advanced materials, such as liquid crystals or organic electronic components.
• Fluorine Chemistry Studies: Acts as a model compound in academic and industrial research focused on introducing fluorinated groups into complex heterocyclic systems.

Basic Information

Product Name	(S)-1-(5-Bromopyridin-3-Yl)-2,2,2-Trifluoroethanol
CAS No.	2227712-52-7
Molecular Formula	C7H5BrF3NO
Molecular Weight	256.02 g/mol
Synonyms	(S)-1-(5-Bromo-3-pyridyl)-2,2,2-trifluoroethanol; (S)-5-Bromo-3-(2,2,2-trifluoro-1-hydroxyethyl)pyridine; (S)-α-(Trifluoromethyl)-5-bromo-3-pyridinemethanol; (S)-2,2,2-Trifluoro-1-(5-bromopyridin-3-yl)ethanol; (S)-1-(5-Bromo-3-pyridinyl)-2,2,2-trifluoroethanol; (S)-3-(2,2,2-Trifluoro-1-hydroxyethyl)-5-bromopyridine
EINECS	Contact for details

Quality Control

Our production of (S)-1-(5-Bromopyridin-3-Yl)-2,2,2-Trifluoroethanol adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR, and GC/HPLC for purity and impurity profiling. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to ensure full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.