Description

Slc13A5-In-1 is a potent and selective small-molecule inhibitor of the sodium-dependent citrate transporter SLC13A5. This compound is a critical research tool for investigating citrate metabolism, neuronal excitability, and their roles in metabolic disorders and epilepsy. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, metabolic disease research, and drug discovery programs.

Application

• Neuroscience Research: Used to study the role of SLC13A5 in regulating neuronal citrate levels and its impact on synaptic function and neuronal excitability.
• Epilepsy Research: Investigated as a potential pharmacological tool for understanding and modeling SLC13A5-related epileptic encephalopathy.
• Metabolic Disorder Studies: Applied in research on hepatic metabolism, lipid synthesis, and the pathophysiology of conditions linked to citrate transport dysregulation.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the design and screening of novel SLC13A5 inhibitors for therapeutic applications.
• Biochemical Assay Development: Employed as a standard in high-throughput screening (HTS) and functional assays to characterize SLC13A5 transporter activity.
• Cell Biology: Used in in vitro cell culture models to dissect the cellular consequences of inhibiting citrate uptake.

Basic Information

Product Name	Slc13A5-In-1
CAS No.	2227548-95-8
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	Slc13A5-In-1; SLC13A5 Inhibitor; Sodium-dependent citrate transporter inhibitor; 2-[[4-[[4-(2-Methoxyphenyl)piperazin-1-yl]methyl]phenyl]sulfonyl]-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile; PF-06649298; PF 06649298; PF06649298; (6-Cyano-3,4-dihydro-2-[[4-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]phenyl]sulfonyl]-1(2H)-isoquinolinyl)acetonitrile
EINECS	Contact for details

Quality Control

Our Slc13A5-In-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability, consistency, and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.