Description

Aurora Inhibitor 1 CAS NO 2227019-45-4 is a potent and selective small molecule inhibitor designed to target Aurora kinases, key regulators of cell cycle progression and mitosis. This compound is critical for researchers and developers in oncology and cell biology, offering a precise tool for investigating mitotic pathways and developing novel therapeutic strategies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cancer drug discovery and cellular mechanism studies.

Application

• Oncology Research & Drug Discovery: A key biochemical tool for studying the role of Aurora kinases in tumor cell proliferation and for screening potential anti-cancer agents.
• Cell Cycle & Mitosis Studies: Used in academic and industrial laboratories to dissect the molecular mechanisms of mitosis, spindle assembly, and chromosome segregation.
• Biomarker Development: Serves as a reference compound in assays designed to identify and validate biomarkers associated with Aurora kinase activity in disease states.
• High-Throughput Screening (HTS): Employed as a positive control or reference standard in HTS campaigns targeting kinase inhibition for new lead identification.
• Preclinical Development: Supports in vitro and in vivo pharmacokinetic/pharmacodynamic (PK/PD) studies during the early stages of anticancer therapeutic development.
• Chemical Biology Probes: Acts as a foundational structure for creating more selective probes to map kinase signaling networks and protein-protein interactions.

Basic Information

Product Name	Aurora Inhibitor 1
CAS No.	2227019-45-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Aurora Kinase Inhibitor 1; Aurora A/B Kinase Inhibitor; Mitotic Kinase Inhibitor; Research Compound 2227019-45-4; Aurora Inhibitor; Cell Cycle Inhibitor 2227019-45-4; Experimental Kinase Modulator
EINECS	Contact for details

Quality Control

Every batch of Aurora Inhibitor 1 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and potency. Our products are supported by a detailed Certificate of Analysis (COA) that includes data from advanced techniques such as HPLC, NMR, and mass spectrometry. We are committed to supplying material that meets the stringent requirements of research and development, with specifications tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under desiccated conditions. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity (IC50)	Reported value provided

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.