Description

6-Bromo-5-Fluoropyridine-3-Boronic Acid is a high-value, multi-functional boronic acid derivative essential for modern synthetic chemistry. Its core value lies in its dual functionality, serving as a versatile building block for constructing complex heterocyclic scaffolds through cross-coupling reactions. This compound is critically needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by material scientists exploring advanced functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used to construct pyridine-based active ingredients for next-generation herbicides, fungicides, and insecticides.
• Ligand & Catalyst Development: Serves as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where the pyridine-boronic acid motif is valuable.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs serving the global life sciences market.

Basic Information

Product Name	6-Bromo-5-Fluoropyridine-3-Boronic Acid
CAS No.	2225178-15-2
Molecular Formula	C5H4BBrFNO2
Molecular Weight	219.81 g/mol
Synonyms	(6-Bromo-5-fluoropyridin-3-yl)boronic acid; 5-Fluoro-6-bromopyridine-3-boronic acid; 3-Borono-6-bromo-5-fluoropyridine; 6-Bromo-5-fluoro-3-pyridineboronic acid; Boronic acid, B-(6-bromo-5-fluoro-3-pyridinyl)-; 2225178-15-2; 6-Br-5-F-3-PyB(OH)2
EINECS	Contact for details

Quality Control

Our 6-Bromo-5-Fluoropyridine-3-Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance in sensitive cross-coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.