Description

4-Fluoro-3-Bromopyridine-5-Boronic Acid Pinacol Ester is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. Its core value lies in enabling precise cross-coupling reactions, such as Suzuki-Miyaura couplings, to construct complex molecular architectures with high efficiency and selectivity. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the discovery and synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides by introducing the fluorinated, brominated pyridine scaffold into lead structures.
• Material Science Research: Serves as a building block for constructing organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and tags for studying biological processes due to its versatile reactivity.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries via parallel and combinatorial chemistry approaches in high-throughput screening.
• Ligand and Catalyst Preparation: Used to synthesize sophisticated ligands for transition metal catalysts used in asymmetric synthesis.

Basic Information

Item	Details
Product Name	4-Fluoro-3-Bromopyridine-5-Boronic Acid Pinacol Ester
CAS No.	2223012-18-6
Molecular Formula	C11H12BBrFNO2
Molecular Weight	300.94 g/mol
Synonyms	5-Boronic Acid, 4-Fluoro-3-bromopyridine-, Pinacol Ester; (4-Fluoro-3-bromopyridin-5-yl)boronic Acid Pinacol Ester; 4-Fluoro-3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Bromo-4-fluoropyridine-5-boronic Acid Pinacol Ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-fluoro-3-bromopyridine; CAS 2223012-18-6; Boronic ester derivative of 4-fluoro-3-bromopyridine.
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Bromopyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC/MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for GMP-ready intermediates in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and reactivity. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.