Description

Dynarrestin is a potent and selective small-molecule inhibitor of the AAA+ ATPase p97/VCP, a key regulator of protein homeostasis and cellular stress response pathways. This compound is a critical research tool for investigating the role of p97 in processes such as endoplasmic reticulum-associated degradation (ERAD), autophagy, and DNA damage repair. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, neurodegenerative disease, and proteostasis research. The product is supplied as a high-purity reference standard to ensure reliable and reproducible experimental results.

Application

• Biomedical Research: A key reagent for studying p97/VCP function in cellular models of cancer, neurodegeneration (e.g., ALS, Alzheimer's), and other protein aggregation diseases.
• Mechanistic Biology: Used to dissect the role of p97 in specific pathways like ERAD, autophagy, and the ubiquitin-proteasome system (UPS).
• Drug Discovery & Target Validation: Serves as a pharmacological probe to validate p97 as a therapeutic target in preclinical studies and high-throughput screening assays.
• Academic & Institutional Research: Essential for laboratories focusing on cell biology, biochemistry, and molecular pharmacology to explore novel therapeutic interventions.
• Biomarker Development: Assists in research aimed at identifying biomarkers associated with p97 inhibition and related cellular stress responses.

Basic Information

Product Name	Dynarrestin
CAS No.	2222768-84-3
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	Dynarrestin; VCP/p97 Inhibitor; p97 Inhibitor; AAA-ATPase Inhibitor; 2-[(4-{[(3S)-3-Methyl-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}phenyl)amino]-4-(4-methylpiperazin-1-yl)pyrimidine-5-carboxamide; CB-6644; (S)-2-((4-((3-Methyl-4-oxo-3,4-dihydroquinazolin-2-yl)thio)phenyl)amino)-4-(4-methylpiperazin-1-yl)pyrimidine-5-carboxamide
EINECS	Contact for details

Quality Control

Our Dynarrestin is manufactured under strict quality management systems to ensure the highest standards of purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical characterization, including identity confirmation by spectroscopic methods (NMR, MS) and purity assessment by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications for your records and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.