Description

Dclk1-In-1 CAS NO 2222635-15-4 is a potent and selective small-molecule inhibitor of Doublecortin-like kinase 1 (DCLK1), a key regulatory protein implicated in various cellular signaling pathways. This compound is a critical research tool for investigating the role of DCLK1 in oncology, neurobiology, and stem cell biology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on target validation and preclinical drug discovery.

Application

• Oncology Research: Investigation of DCLK1's role in tumor initiation, progression, metastasis, and cancer stem cell maintenance.
• Neurobiological Studies: Exploration of DCLK1 function in neuronal migration, differentiation, and neurological disorders.
• Stem Cell Biology: Research into the regulation of stemness and differentiation pathways in various cell types.
• Target Validation: Functional characterization of DCLK1 as a therapeutic target in various disease models.
• Biochemical Assay Development: Use as a reference standard in high-throughput screening (HTS) and kinase profiling assays.
• Preclinical Drug Discovery: Serving as a lead compound or pharmacophore model for the development of novel DCLK1-targeted therapeutics.

Basic Information

Product Name	Dclk1-In-1
CAS No.	2222635-15-4
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	DCLK1-IN-1; DCLK1 Inhibitor; 2-[[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]amino]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidine-4-carboxamide; DCLK1 Kinase Inhibitor; Doublecortin-like kinase 1 inhibitor; 2222635-15-4
EINECS	Contact for details

Quality Control

Our Dclk1-In-1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure high chemical integrity and batch-to-batch consistency suitable for research applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.