Description

2-(Difluoromethoxy)Nicotinaldehyde is a high-value fluorinated pyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique difluoromethoxy-substituted nicotinaldehyde structure makes it indispensable for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation pesticides and herbicides, where the difluoromethoxy group can enhance biological activity and stability.
• Material Science Research: Serves as a precursor for creating specialized fluorinated ligands and functional materials with unique electronic or surface properties.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes and tags for studying biological mechanisms and diagnostics.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-(Difluoromethoxy)Nicotinaldehyde
CAS No.	2222104-51-8
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	2-(Difluoromethoxy)pyridine-3-carbaldehyde; Nicotinaldehyde, 2-(difluoromethoxy)-; 3-Pyridinecarboxaldehyde, 2-(difluoromethoxy)-; 2-Difluoromethoxynicotinaldehyde; 2-(Difluoromethoxy)-3-formylpyridine
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Nicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.