Description

Rheb Inhibitor Nr1 is a potent and selective small molecule inhibitor of the Ras homolog enriched in brain (Rheb) protein, a key activator of the mTORC1 signaling pathway. This compound is a critical research tool for investigating cellular growth, metabolism, and autophagy, with significant implications for oncology and metabolic disease research. It is essential for pharmaceutical R&D, academic laboratories, and biotechnology companies focused on mTOR pathway biology and therapeutic target validation.

Application

• Biomedical Research: Fundamental studies on the mTORC1 signaling pathway, its regulation, and downstream effects.
• Oncology Research: Investigation of tumor cell proliferation, survival, and metabolism in various cancer models.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening and lead optimization for mTOR-targeted therapies.
• Metabolic Disease Studies: Research into conditions like diabetes and obesity where mTOR signaling plays a regulatory role.
• Neuroscience Research: Exploration of Rheb and mTOR functions in neuronal development, synaptic plasticity, and neurodegenerative diseases.
• Cell Biology & Biochemistry: Mechanistic studies of autophagy, lysosomal function, and cellular response to nutrients and stress.

Basic Information

Product Name	Rheb Inhibitor Nr1
CAS No.	2216763-38-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Rheb Inhibitor Nr1; Rheb inhibitor; mTORC1 Signaling Inhibitor; Rheb-mTOR Inhibitor; 2216763-38-9; Rheb protein inhibitor; (S)-2-(4-(4-(3-(2-Amino-5-chloropyridin-3-yl)-1H-pyrazol-4-yl)pyridin-2-yl)piperazin-1-yl)ethanol (IUPAC name candidate); NR1 Rheb Inhibitor
EINECS	Contact for details

Quality Control

Our Rheb Inhibitor Nr1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing batch-to-batch consistency and reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.