Description

(S)-(-)-Ofloxacin-D3 (n-Methyl-D3) is a deuterium-labeled isotopologue of the chiral fluoroquinolone antibiotic ofloxacin, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative mass spectrometry methods, particularly in pharmacokinetic and bioanalytical studies. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, contract research organization (CRO), and clinical diagnostics sectors who require precise measurement of ofloxacin and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, non-interfering internal standard for the quantitative bioanalysis of ofloxacin in biological matrices (plasma, serum, urine, tissue).
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Pharmaceutical Quality Control: Used in assay development and validation to ensure the potency and purity of ofloxacin-based drug products.
• Veterinary Drug Residue Testing: Supports regulatory compliance testing for ofloxacin residues in food-producing animals.
• Environmental Analysis: Facilitates the detection and quantification of ofloxacin traces in environmental water samples.
• Method Development & Validation: Serves as a key reagent for developing robust, reproducible, and GLP-compliant analytical methods.

Basic Information

Product Name	(S)-(-)-Ofloxacin-D3 (n-Methyl-D3)
CAS No.	2208780-63-4
Molecular Formula	C18H17D3FN3O4
Molecular Weight	364.38 g/mol
Synonyms	(S)-(-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl-d3)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid; (S)-Ofloxacin-methyl-d3; (-)-(S)-Ofloxacin-N-methyl-d3; Levofloxacin Impurity (Levofloxacin Related Compound); Ofloxacin D3 Internal Standard; Ofloxacin-d3 (N-methyl); Deuterated Ofloxacin
EINECS	Contact for details

Quality Control

Every batch of (S)-(-)-Ofloxacin-D3 (n-Methyl-D3) is manufactured and analyzed under strict quality systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic techniques, to ensure compliance with the high-purity standards required for analytical applications. A comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical purity, and identity confirmation is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storage under inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.