Description

Protac Brd4 Degrader-2 is a potent and selective small-molecule degrader designed for targeted protein degradation research. This compound is a critical tool for investigating the role of BRD4 in epigenetic regulation and disease pathways, offering a powerful alternative to traditional inhibition. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on oncology, inflammatory diseases, and the development of novel therapeutic modalities like PROTACs.

Application

• PROTAC & Targeted Protein Degradation Research: Serves as a key chemical probe for validating and optimizing PROTAC (Proteolysis Targeting Chimera) technology platforms.
• Epigenetics & Oncology Studies: Used to study BRD4 function and its role in cancer cell proliferation, survival, and tumor progression.
• Drug Discovery & Preclinical Development: Acts as a reference standard or lead compound in the discovery of novel BET protein degraders for therapeutic applications.
• Biochemical & Cellular Mechanism Studies: Enables investigation of ubiquitin-proteasome system (UPS) engagement, ternary complex formation, and degradation kinetics.
• High-Throughput Screening (HTS): Employed as a control or tool compound in screening assays to identify new degraders or modulators of protein degradation pathways.

Basic Information

Product Name	Protac Brd4 Degrader-2
CAS No.	2185795-53-1
Molecular Formula	C31H34ClN5O5S
Molecular Weight	624.15 g/mol
Synonyms	PROTAC BRD4 Degrader-2; ARV-825; (S,R,S)-AHPC-PEG4-OTBS PROTAC; BET Degrader ARV-825; BRD4 Degrader-2; (S,R,S)-AHPC-C4-O-C4-O-C4-O-C4-NH-Piperazine-OtBu; ARV 825; (S,R,S)-AHPC-PEG4-C2-NH-Piperazine-OtBu
EINECS	Contact for details

Quality Control

Our Protac Brd4 Degrader-2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.