Description

Gcn2-In-6 CAS NO 2183470-09-7 is a potent and selective small-molecule inhibitor of the GCN2 (General Control Nonderepressible 2) kinase, a key regulator of the integrated stress response (ISR). This compound is a critical research tool for investigating cellular stress pathways, protein synthesis regulation, and their implications in oncology, immunology, and neurodegenerative diseases. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on target validation and therapeutic discovery.

Application

• Biomedical Research: A key reagent for studying the molecular mechanisms of the integrated stress response (ISR) and amino acid sensing pathways in cell culture models.
• Oncology Research: Used to investigate the role of GCN2 in tumor microenvironment adaptation, immune evasion, and as a potential therapeutic target for cancer therapy development.
• Immunology Studies: Employed to explore GCN2 function in T-cell activation, differentiation, and its impact on immune checkpoint regulation.
• Neurodegenerative Disease Models: Applied in research models to understand the contribution of cellular stress and translational control to diseases like Alzheimer's and Parkinson's.
• Drug Discovery & Target Validation: Serves as a pharmacological probe for high-throughput screening, lead optimization, and validating GCN2 as a druggable target in various therapeutic areas.
• Preclinical Development: Supports in vivo studies in animal models to assess the efficacy and pharmacokinetics of targeting the GCN2 pathway.

Basic Information

Product Name	Gcn2-In-6
CAS No.	2183470-09-7
Molecular Formula	C₂₄H₂₃N₅O₃
Molecular Weight	429.48 g/mol
Synonyms	GCN2-IN-6; GCN2 Inhibitor 6; 2-[[4-(4-Methylpiperazin-1-yl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 2-({4-[(4-Methyl-1-piperazinyl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; GCN2 Kinase Inhibitor; General Control Nonderepressible 2 Inhibitor 6
EINECS	Contact for details

Quality Control

Our Gcn2-In-6 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.