Description

Kdm2A/7A-In-1 CAS NO 2169272-46-0 is a potent, dual-targeting small molecule inhibitor designed for epigenetic research. This compound matters as a valuable chemical tool for selectively modulating histone demethylase activity, enabling the study of gene regulation and cellular differentiation. It is primarily needed by researchers and pharmaceutical developers in the fields of oncology, neurobiology, and stem cell research for target validation and drug discovery efforts.

Application

• Epigenetics Research: Used as a selective chemical probe to inhibit KDM2A and KDM7A subfamily histone demethylases in cellular and biochemical assays.
• Oncology Target Validation: Investigates the role of specific histone demethylases in cancer cell proliferation, survival, and tumor progression.
• Stem Cell & Developmental Biology: Studies the impact of histone methylation dynamics on cell fate decisions, differentiation, and reprogramming.
• Neurological Disease Models: Explores epigenetic mechanisms in neurological disorders for potential therapeutic pathway identification.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in screening campaigns for novel epigenetic modulators.
• Biochemical Mechanism Studies: Elucidates enzyme kinetics, substrate specificity, and inhibitor binding modes of lysine-specific demethylases.

Basic Information

Product Name	Kdm2A/7A-In-1
CAS No.	2169272-46-0
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	KDM2A/7A Inhibitor; KDM2A/KDM7A Inhibitor; JHDM1 Inhibitor; Histone Demethylase Inhibitor; 2169272-46-0; KDM2A Inhibitor; KDM7A Inhibitor; Dual KDM2/7 Inhibitor
EINECS	Contact for details

Quality Control

Our Kdm2A/7A-In-1 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) with detailed specifications are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to warm to room temperature before opening to minimize moisture condensation. Keep the container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.