Description

4-Bromo-3-(Trifluoromethoxy)Toluene is a high-value halogenated aromatic building block characterized by its bromine and trifluoromethoxy substituents. This compound is essential for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry, ligand synthesis, and the development of functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders or possessing fluorinated motifs for enhanced metabolic stability.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the bromine atom serves as a handle for further functionalization.
• Ligand & Catalyst Development: Employed in the creation of sophisticated ligands for transition metal catalysis, leveraging the electron-withdrawing trifluoromethoxy group to tune catalytic activity.
• Material Science Precursor: Serves as a monomer or building block for advanced polymers, liquid crystals, or organic electronic materials requiring specific halogenated aromatic units.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes, where the bromine allows for further bioconjugation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	4-Bromo-3-(Trifluoromethoxy)Toluene
CAS No.	2166854-28-8
Molecular Formula	C9H6BrF3O
Molecular Weight	267.04 g/mol
Synonyms	1-Bromo-2-methyl-4-(trifluoromethoxy)benzene; 4-Bromo-3-(trifluoromethoxy)-1-methylbenzene; 2-Methyl-4-(trifluoromethoxy)bromobenzene; 3-(Trifluoromethoxy)-4-bromotoluene; Toluene, 4-bromo-3-(trifluoromethoxy)-; α,α,α-Trifluoro-4-bromo-3-methylphenyl ether
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-(Trifluoromethoxy)Toluene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with ISO, cGMP, and REACH standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.