Description

Sirt5 Inhibitor CAS NO 2166487-21-2 is a potent and selective small molecule compound designed to target and inhibit the activity of the Sirtuin 5 (SIRT5) enzyme. This compound is a critical research tool for investigating the role of SIRT5 in metabolic regulation, cellular signaling, and disease pathology, particularly in oncology and neurodegenerative research. It is essential for pharmaceutical R&D, academic laboratories, and biotechnology companies focused on developing novel therapeutic strategies targeting sirtuin pathways.

Application

• Biochemical Research: Used as a selective probe to study SIRT5's demalonylase and desuccinylase activity in vitro and in cellular assays.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and medicinal chemistry programs aimed at developing SIRT5-targeted therapeutics.
• Oncology Research: Investigated for its potential to modulate cancer cell metabolism and proliferation in studies exploring SIRT5's role in tumorigenesis.
• Metabolic Disease Studies: Applied in research models to understand SIRT5's function in mitochondrial metabolism, fatty acid oxidation, and their links to metabolic disorders.
• Neuroscience Research: Utilized in exploring the connection between SIRT5 activity, reactive oxygen species (ROS) management, and neurodegenerative conditions.
• Epigenetics & Cell Signaling: A key reagent for dissecting the impact of lysine malonylation and succinylation on protein function and cellular signaling pathways.

Basic Information

Product Name	Sirt5 Inhibitor
CAS No.	2166487-21-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	SIRT5 Inhibitor; SIRT5 Inhibitor, Selective; Sirtuin 5 Inhibitor; (2E)-3-(4-((3-(Trifluoromethyl)benzyl)oxy)phenyl)acrylic acid; SIRT5i; CAS 2166487-21-2
EINECS	Contact for details

Quality Control

Our Sirt5 Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability for research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.