Description

Mcl-1/Bcl-2-In-3 is a potent and selective small-molecule inhibitor targeting the anti-apoptotic Bcl-2 family proteins Mcl-1 and Bcl-2. This compound matters for its role as a critical research tool in oncology and apoptosis studies, enabling the investigation of programmed cell death pathways. It is needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel cancer therapeutics, particularly for hematological malignancies and solid tumors where these proteins are overexpressed.

Application

• Biochemical Research: Used as a reference standard and probe compound in apoptosis signaling pathway studies.
• Oncology Drug Discovery: Serves as a lead compound or pharmacophore model for developing novel anti-cancer agents targeting Bcl-2 family proteins.
• Mechanistic Studies: Employed in in vitro assays to understand the functional roles of Mcl-1 and Bcl-2 in cell survival and resistance to chemotherapy.
• High-Throughput Screening (HTS): Utilized as a control or validation compound in screening campaigns to identify new apoptosis modulators.
• Preclinical Development: Supports pharmacokinetic (PK), pharmacodynamic (PD), and efficacy studies in relevant animal models of cancer.

Basic Information

Product Name	Mcl-1/Bcl-2-In-3
CAS No.	2163793-55-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Mcl-1/Bcl-2 Inhibitor 3; Bcl-2/Mcl-1 dual inhibitor 3; Mcl-1-Bcl-2-In-3; 2163793-55-1; Mcl-1/Bcl-2 dual inhibitor; Apoptosis inhibitor antagonist; Bcl-2 family protein inhibitor
EINECS	Contact for details

Quality Control

Our Mcl-1/Bcl-2-In-3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and NMR/LC-MS for structural identity, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.