Description

Protac Mcl1 Degrader-1 is a potent and selective small molecule degrader designed to target the myeloid cell leukemia 1 (Mcl-1) protein via proteolysis-targeting chimera (PROTAC) technology. This compound is a critical research tool for investigating Mcl-1's role in apoptosis and for developing novel cancer therapeutics, particularly in treatment-resistant tumors. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on oncology, targeted protein degradation, and apoptosis pathway studies.

Application

• Oncology Research: A key chemical probe for studying the role of Mcl-1 in cancer cell survival, proliferation, and resistance to chemotherapy.
• Drug Discovery & Development: Used as a reference standard and a starting point for developing novel PROTAC-based anticancer agents targeting anti-apoptotic Bcl-2 family proteins.
• Biochemical Assays: Employed in in vitro and cellular assays to validate PROTAC mechanism of action, including ubiquitination, proteasomal degradation, and apoptosis induction.
• Target Validation: Facilitates the pharmacological validation of Mcl-1 as a therapeutic target in various hematological and solid tumor models.
• Preclinical Studies: Supports pharmacokinetics, pharmacodynamics, and efficacy studies in animal models of cancer.

Basic Information

Product Name	Protac Mcl1 Degrader-1
CAS No.	2163793-38-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Mcl-1 Degrader-1; Mcl-1 PROTAC Degrader; Mcl-1 Degrader-1; (S,R,S)-AHPC-Mcl1 ligand conjugate 1; VHL-based Mcl-1 degrader; Mcl1-PROTAC; Degrader of Mcl-1
EINECS	Contact for details

Quality Control

Our Protac Mcl1 Degrader-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a desiccator to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.