Description

Protac Er Degrader-3 is a potent and selective small molecule degrader designed for targeted protein degradation research. This compound is a critical tool for investigating estrogen receptor (ER) biology and developing novel therapeutic strategies in oncology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cancer drug discovery and proteolysis-targeting chimera (PROTAC) technology.

Application

• PROTAC & Targeted Protein Degradation Research: A core chemical tool for studying the mechanism and efficacy of proteolysis-targeting chimeras.
• Estrogen Receptor (ER) Biology Studies: Used to selectively degrade ER proteins to elucidate their role in cellular pathways and disease states.
• Oncology Drug Discovery: Serves as a lead compound or reference standard in the development of novel cancer therapeutics, particularly for hormone-receptor-positive cancers.
• Biochemical & Cellular Assay Development: Employed in high-throughput screening (HTS) and validation assays to identify and characterize new degraders.
• Mechanism of Action (MOA) Studies: Facilitates research into ubiquitin-proteasome system (UPS) engagement and degradation kinetics.

Basic Information

Product Name	Protac Er Degrader-3
CAS No.	2158322-29-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC ER Degrader-3; ER Degrader-3; ARV-471 analogue; PROTAC Estrogen Receptor Degrader 3; Estrogen Receptor-targeting PROTAC; Degrader of Estrogen Receptor; PROTAC molecule for ERα/ERβ; Bifunctional ER degrader
EINECS	Contact for details

Quality Control

Our Protac Er Degrader-3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC purity analysis and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic and spectral data are provided to guarantee reproducibility and reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the vial to warm to room temperature before opening to minimize moisture condensation. Store under inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	<1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.