Description

3-Bromo-2,4,6-Trifluorobenzenesulfonyl Chloride is a high-value, multi-functional chemical building block essential for advanced organic synthesis. Its core value lies in its unique halogenated and sulfonyl chloride structure, enabling precise molecular modifications in complex chemical architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs and fluorine-containing bioactive molecules.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoro and bromo substituents confer desirable biological activity and environmental stability.
• Material Science Building Block: Employed in the creation of specialty polymers, liquid crystals, and advanced electronic materials requiring specific halogen and sulfonyl functionalities.
• Cross-Coupling Reactions: Serves as a versatile electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Sulfonamide & Sulfonate Formation: The reactive sulfonyl chloride group is ideal for the efficient preparation of sulfonamides, sulfonate esters, and other sulfonyl derivatives under mild conditions.
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and the development of chemical probes targeting specific enzymes or biological pathways.

Basic Information

Product Name	3-Bromo-2,4,6-Trifluorobenzenesulfonyl Chloride
CAS No.	2154410-88-3
Molecular Formula	C6HBrClF3O2S
Molecular Weight	315.48 g/mol
Synonyms	2,4,6-Trifluoro-3-bromobenzenesulfonyl chloride; 3-Bromo-2,4,6-trifluorobenzene-1-sulfonyl chloride; Benzenesulfonyl chloride, 3-bromo-2,4,6-trifluoro-; 3-Bromo-2,4,6-trifluorophenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Bromo-2,4,6-Trifluorobenzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. Certificates of Analysis (COA) with full characterization data are provided to guarantee compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.