Description

Alpha,2-Dimethyl-3-(Trifluoromethyl)Benzyl Bromide is a high-value, multi-functional benzyl bromide derivative, distinguished by its trifluoromethyl and dimethyl substituents which impart unique reactivity and lipophilicity. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the creation of monomers and functional additives for advanced polymers and liquid crystal materials.
• Fluorine Chemistry: An essential reagent for introducing the benzyl bromide moiety adjacent to a trifluoromethyl group, a valuable motif in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under GMP or ISO guidelines.

Basic Information

Product Name	Alpha,2-Dimethyl-3-(Trifluoromethyl)Benzyl Bromide
CAS No.	2149597-33-9
Molecular Formula	C11H12BrF3
Molecular Weight	281.11 g/mol
Synonyms	1-(Bromomethyl)-2,3-dimethyl-4-(trifluoromethyl)benzene; (2,3-Dimethyl-4-(trifluoromethyl)phenyl)methyl bromide; 2,3-Dimethyl-α-(bromomethyl)benzotrifluoride; 4-(Trifluoromethyl)-2,3-dimethylbenzyl bromide; 3-(Trifluoromethyl)-2,6-dimethylbenzyl bromide; Benzene, 1-(bromomethyl)-2,3-dimethyl-4-(trifluoromethyl)-; Bromo(2,3-dimethyl-4-(trifluoromethyl)phenyl)methane
EINECS	Contact for details

Quality Control

Our Alpha,2-Dimethyl-3-(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.