Description

2Bact (Eif2B Activator 2Bact) is a potent and selective small molecule activator of the eukaryotic translation initiation factor 2B (eIF2B). This compound matters because it directly modulates the integrated stress response (ISR) pathway, offering a powerful tool for research into cellular stress, protein synthesis regulation, and related neurological disorders. Researchers and pharmaceutical developers in the fields of neurobiology, biochemistry, and drug discovery require this high-purity chemical for probing disease mechanisms and developing novel therapeutic strategies.

Application

• Biochemical Research: Used as a critical tool compound to activate eIF2B and study the integrated stress response (ISR) pathway in vitro.
• Neuroscience Studies: Applied in models of neurodegenerative diseases (e.g., Vanishing White Matter disease, Alzheimer's) to investigate the role of translational control.
• Cell Signaling Pathways: Employed to elucidate mechanisms of cellular adaptation to various stresses such as nutrient deprivation, viral infection, and oxidative stress.
• Drug Discovery & Screening: Serves as a reference standard and positive control in high-throughput assays targeting the eIF2B complex for novel therapeutic development.
• Academic & Institutional Research: Essential for universities and research institutes conducting fundamental research on protein synthesis and cellular homeostasis.

Basic Information

Product Name	2Bact (Eif2B Activator 2Bact)
CAS No.	2143542-28-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2Bact; EIF2B Activator; eIF2B Activator 2Bact; ISRIB-like compound; Integrated Stress Response Inhibitor; Eukaryotic Translation Initiation Factor 2B Activator; 2Bact research compound; eIF2B modulator
EINECS	Contact for details

Quality Control

Our 2Bact is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to confirm identity and potency. A detailed Certificate of Analysis (COA) documenting purity, assay results, and analytical spectra is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.