Description

Zikv Inhibitor K22 is a potent and selective small-molecule inhibitor of the Zika virus (ZIKV) NS4B protein, identified by CAS registry number 2141978-86-9. This compound is a critical research tool for virologists and pharmaceutical developers aiming to understand viral replication mechanisms and develop novel antiviral therapeutics. It is essential for high-throughput screening, lead optimization, and preclinical studies within antiviral drug discovery and infectious disease research.

Application

• Antiviral Research & Development: Primary tool for studying Zika virus replication and inhibition mechanisms in vitro.
• High-Throughput Screening (HTS): Used as a reference compound or positive control in assays to discover new antiviral agents.
• Lead Compound Optimization: Serves as a structural scaffold for medicinal chemistry programs to improve potency, selectivity, and pharmacokinetic properties.
• Preclinical Studies: Evaluation of efficacy and toxicity in cell-based and animal models of ZIKV infection.
• Mechanistic Virology: Investigating the role of the NS4B protein in the ZIKV life cycle and host-pathogen interactions.
• Chemical Biology Probes: Utilized to study protein function and validate NS4B as a therapeutic target for flaviviruses.

Basic Information

Product Name	Zikv Inhibitor K22
CAS No.	2141978-86-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	K22; ZIKV inhibitor K22; Zika virus inhibitor K22; NS4B inhibitor K22; 2-[(4-Methylphenyl)sulfonyl]-N-[5-(1-pyrrolidinylsulfonyl)-2-pyridinyl]acetamide (IUPAC); 2-(p-Tolylsulfonyl)-N-[5-(pyrrolidin-1-ylsulfonyl)pyridin-2-yl]acetamide
EINECS	Contact for details

Quality Control

Our Zikv Inhibitor K22 is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications for your records and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.