Description

Ripk2-In-8 CAS NO 2141969-56-2 is a potent and selective small-molecule inhibitor of Receptor-Interacting Protein Kinase 2 (RIPK2), a key signaling node in the NOD1 and NOD2 pathways. This compound is a critical research tool for investigating inflammatory and autoimmune diseases, offering high specificity to minimize off-target effects. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on immunology, oncology, and the development of novel therapeutics targeting innate immune signaling.

Application

• Biochemical Research: Used as a selective probe to study the role of RIPK2 in NOD1/NOD2-mediated NF-κB and MAPK signaling pathways.
• Drug Discovery & Preclinical Studies: Serves as a lead compound or reference standard in high-throughput screening and hit-to-lead optimization for inflammatory disease targets.
• Immunology & Autoimmunity Research: Investigates the involvement of RIPK2 in conditions like Crohn's disease, ulcerative colitis, and Blau syndrome.
• Oncology Research: Explores the connection between chronic inflammation, RIPK2 activity, and tumorigenesis in certain cancer models.
• Cellular Assay Development: Employed to validate cellular assays and establish potency (IC50) for RIPK2 inhibitory activity.
• Mechanism of Action (MoA) Studies: Helps elucidate downstream effects and crosstalk of RIPK2 inhibition within complex cellular networks.

Basic Information

Product Name	Ripk2-In-8
CAS No.	2141969-56-2
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	RIPK2-IN-8; RIPK2 Inhibitor-8; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(4-fluorophenyl)-6-(4-morpholinyl)-N-(1-piperidinylmethyl)-; 1-(4-Fluorophenyl)-6-morpholino-N-(piperidin-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; GSK583; GSK'583
EINECS	Contact for details

Quality Control

Our Ripk2-In-8 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency, meeting the high standards required for research and development. A detailed Certificate of Analysis (COA) providing HPLC purity, NMR confirmation, and mass spectrometry data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.