Description

Atm Inhibitor-1 CAS NO 2135639-94-8 is a potent and selective small molecule inhibitor of the Ataxia Telangiectasia Mutated (ATM) kinase, a key regulator of the DNA damage response pathway. This compound is essential for advanced research in oncology and cellular biology, enabling the study of DNA repair mechanisms and their role in cancer progression and treatment resistance. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel cancer therapeutics and understanding genomic stability.

Application

• Oncology Research: Used as a critical tool compound to inhibit ATM kinase activity in cell-based and in vivo studies of various cancers, including breast, pancreatic, and hematological malignancies.
• DNA Damage Response (DDR) Pathway Analysis: Enables the dissection of the ATM-mediated signaling cascade following genotoxic stress, helping to identify synthetic lethal interactions and therapeutic vulnerabilities.
• Radiosensitization Studies: Investigated for its potential to enhance the efficacy of radiotherapy by impairing cancer cells' ability to repair radiation-induced DNA double-strand breaks.
• Chemotherapy Combination Research: Explored in combination with DNA-damaging chemotherapeutic agents (e.g., topoisomerase inhibitors, platinum-based drugs) to overcome treatment resistance.
• Biomarker Discovery: Facilitates research into predictive biomarkers for ATM inhibitor sensitivity and patient stratification strategies in clinical oncology.
• Preclinical Drug Development: Serves as a reference standard and pharmacodynamic tool in the discovery and validation stages of next-generation DDR inhibitor programs.

Basic Information

Product Name	Atm Inhibitor-1
CAS No.	2135639-94-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ATM Kinase Inhibitor; ATM Inhibitor; ATM Kinase Inhibitor-1; Compound 2135639-94-8; Ataxia Telangiectasia Mutated Inhibitor-1; DDR Inhibitor (ATM-targeted); Research Compound for ATM Inhibition
EINECS	Contact for details

Quality Control

Our Atm Inhibitor-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for reproducible research outcomes. Each lot undergoes comprehensive analytical characterization, including identity confirmation and purity assessment by advanced chromatographic and spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specifications and test results. We support research compliance and data integrity for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.