Description

Hsp27 Inhibitor J2 is a potent and selective small molecule inhibitor of Heat Shock Protein 27 (Hsp27), a key molecular chaperone implicated in cellular stress response and client protein stabilization. This compound is critical for disrupting oncogenic signaling pathways and inducing apoptosis in cancer cells, particularly those dependent on Hsp27 for survival and drug resistance. It is an essential research tool for oncology, neurobiology, and pharmacology studies, enabling the investigation of protein aggregation diseases and therapeutic target validation. The product is supplied to the global market with a focus on research institutions, pharmaceutical R&D, and biotechnology companies.

Application

• Oncology Research: Used to study the role of Hsp27 in tumor progression, metastasis, and chemoresistance in various cancer cell lines.
• Neurodegenerative Disease Models: Applied in research on Alzheimer's, Parkinson's, and ALS to investigate Hsp27's role in mitigating protein misfolding and aggregation.
• Apoptosis & Cell Stress Pathways: A key reagent for elucidating mechanisms of programmed cell death and cellular response to thermal, oxidative, and chemical stress.
• Drug Discovery & Target Validation: Serves as a pharmacological probe for validating Hsp27 as a therapeutic target in high-throughput screening and lead optimization campaigns.
• Cardioprotection Studies: Utilized in models of ischemic injury to understand the protective functions of Hsp27 in cardiac tissue.
• Signal Transduction Analysis: Employed to dissect downstream signaling networks involving AKT, p38 MAPK, and other pathways regulated by Hsp27 activity.

Basic Information

Product Name	Hsp27 Inhibitor J2
CAS No.	2133499-85-9
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	J2 Hsp27 Inhibitor; Hsp27 Inhibitor, J2; 1H-Pyrrolo[2,3-b]pyridine-5-carboxamide, N-[4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-1-piperazinyl]-2-(1H-pyrrol-1-yl)-; (S)-J2; HspB1 Inhibitor J2; Heat Shock Protein 27 Inhibitor J2; Apoptosis promoter J2
EINECS	Contact for details

Quality Control

Our Hsp27 Inhibitor J2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade standards. We are committed to supplying materials of the highest consistency and reliability for critical scientific applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption. The compound is stable under these conditions for at least two years.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.