Description

Protac Brd4 Degrader-1 CAS NO 2133360-00-4 is a potent and selective small-molecule degrader designed to target the Bromodomain-containing protein 4 (BRD4) via the Proteolysis-Targeting Chimera (PROTAC) mechanism. This compound matters because it offers a novel pharmacological strategy for targeted protein degradation, enabling the study of previously "undruggable" oncogenic targets in cancer research and drug discovery. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing next-generation therapeutics for oncology, inflammatory diseases, and other conditions driven by epigenetic regulation.

Application

• Biochemical Research: A critical tool for investigating BRD4 biology, protein degradation pathways, and epigenetic regulation in cellular models.
• Drug Discovery & Preclinical Development: Used as a lead compound or reference standard in the development of novel PROTAC-based therapeutics targeting BRD4.
• Oncology Research: Facilitates the study of BRD4's role in various cancers, including leukemia, lymphoma, and solid tumors, for target validation and mechanism-of-action studies.
• Pharmacology Studies: Employed to assess the kinetics, efficacy, and selectivity of targeted protein degradation in vitro and in vivo.
• High-Throughput Screening (HTS): Serves as a positive control in assays designed to discover new degraders or modulators of the ubiquitin-proteasome system.

Basic Information

Product Name	Protac Brd4 Degrader-1
CAS No.	2133360-00-4
Molecular Formula	C31H34ClN5O3S
Molecular Weight	592.15 g/mol
Synonyms	PROTAC BRD4 Degrader-1; ARV-825; (S,R,S)-AHPC-Me; (S,R,S)-AHPC-methyl; BET Degrader ARV-825; BRD4 Degrader ARV-825; (S,R,S)-AHPC-C5-NH2 hydrochloride; (2S,4R)-1-((S)-2-(1-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridin-3-yl)oxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((4-(4-methylthiazol-5-yl)phenyl)methyl)pyrrolidine-2-carboxamide
EINECS	Contact for details

Quality Control

Our Protac Brd4 Degrader-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.