Description

Clk1-In-1 is a potent and selective small molecule inhibitor of the CDC-like kinase 1 (CLK1), a key regulator of RNA splicing. This compound is essential for researchers and developers in the life sciences sector, providing a critical tool for modulating pre-mRNA splicing and investigating related disease pathways. It is primarily utilized in pharmaceutical R&D for the study of oncology, neurodegenerative disorders, and virology, where precise control of splicing mechanisms is required.

Application

• Pharmaceutical Research & Development: A key biochemical tool for studying the role of CLK1 in disease models and validating it as a therapeutic target.
• Oncology Research: Investigation of CLK1 inhibition effects on cancer cell proliferation, apoptosis, and tumor growth in preclinical studies.
• Neurodegenerative Disease Studies: Exploration of splicing dysfunction in conditions such as Alzheimer's disease, spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS).
• Antiviral Research: Study of host splicing factor inhibition as a potential strategy against viruses that depend on cellular splicing machinery.
• Chemical Biology & Proteomics: Used as a selective probe to understand CLK1 signaling networks and identify downstream effectors.
• High-Throughput Screening (HTS): Serves as a reference compound and positive control in assay development and drug discovery campaigns.

Basic Information

Product Name	Clk1-In-1
CAS No.	2123491-32-5
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	Clk1-In-1; 2123491-32-5; CLK1 inhibitor; CDC-like kinase 1 inhibitor; 4-[(3S)-3-[[5-Chloro-2-(1H-pyrazol-1-yl)pyrimidin-4-yl]amino]pyrrolidin-1-yl]-6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinoline-3-carbonitrile; 6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-[(3S)-3-[[5-chloro-2-(1H-pyrazol-1-yl)-4-pyrimidinyl]amino]-1-pyrrolidinyl]-3-quinolinecarbonitrile
EINECS	Contact for details

Quality Control

Our Clk1-In-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, keep containers sealed under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.