Description

Allosteric Wnk Kinase Inhibitor is a potent and selective small molecule compound designed to modulate the With-No-Lysine (WNK) kinase signaling pathway. This inhibitor is of significant value for biochemical and pharmacological research, offering a targeted tool for investigating hypertension, renal electrolyte balance, and cellular osmoregulation. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) engaged in cardiovascular disease, kidney function, and novel therapeutic discovery.

Application

• Biochemical Research: Used as a selective probe to study the structure, function, and downstream signaling effects of WNK kinases in in vitro assays.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and hit-to-lead optimization programs for hypertension and renal disorders.
• Mechanistic Studies: Facilitates research into the pathophysiology of pseudohypoaldosteronism type II (PHAII) and other diseases linked to WNK kinase dysregulation.
• Cellular Pathway Analysis: Employed in cell-based models to investigate the role of WNK-SPAK/OSR1 pathways in ion transport and cell volume regulation.
• Target Validation: A critical tool for confirming WNK kinases as viable therapeutic targets in preclinical disease models.
• Reference Standard: Used in analytical laboratories for method development and quality control of related pharmaceutical ingredients.

Basic Information

Product Name	Allosteric Wnk Kinase Inhibitor
CAS No.	2123489-30-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	WNK Kinase Allosteric Inhibitor; WNK Inhibitor; CAS 2123489-30-3; Allosteric Inhibitor of WNK Kinase; (S)-2-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)piperidin-1-yl)-2-oxo-1-phenylethyl 4-chloro-3-methylbenzoate (IUPAC-based); Research Compound 2123489-30-3; Kinase Inhibitor 2123489-30-3
EINECS	Contact for details

Quality Control

Our Allosteric Wnk Kinase Inhibitor is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be sealed under dry conditions and allowed to equilibrate to room temperature before opening to minimize condensation and exposure.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.