Description

Tenofovir Diphosphate Triethylamine is a key nucleotide analog intermediate, specifically the active diphosphate metabolite of Tenofovir. This compound is of critical importance in pharmaceutical research and development, particularly for the synthesis of antiviral prodrugs. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of antiviral therapies, such as those targeting HIV and hepatitis B.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of Tenofovir prodrugs like Tenofovir Disoproxil Fumarate (TDF) and Tenofovir Alafenamide (TAF).
• Antiviral Research: Used as a reference standard and active metabolite in biochemical and pharmacological studies of nucleotide reverse transcriptase inhibitors (NRTIs).
• Mechanistic Studies: Employed in enzymatic assays to study the mechanism of action and resistance profiles of antiviral drugs.
• Analytical Standard: Functions as a high-purity certified reference material (CRM) for quality control and analytical method development (e.g., HPLC, LC-MS).
• Preclinical Development: Essential for in vitro and in vivo studies to evaluate the pharmacokinetics and efficacy of novel antiviral compounds.

Basic Information

Product Name	Tenofovir Diphosphate Triethylamine
CAS No.	2122333-63-3
Molecular Formula	C18H34N6O10P2 • C6H15N
Molecular Weight	Contact for details
Synonyms	Tenofovir Diphosphate TEA Salt; (R)-PMPA Diphosphate Triethylamine Salt; 9-[(R)-2-[[bis[[(Triethylamino)oxy]phosphinyl]methoxy]propyl]adenine; GS-4331 Diphosphate TEA Salt; TDF Intermediate; TAF Intermediate; Tenofovir-PP TEA; PMPA Diphosphate Triethylammonium Salt
EINECS	Contact for details

Quality Control

Our Tenofovir Diphosphate Triethylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Assay (HPLC)	95.0% - 105.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.