Description

2-Chloro-5-(Trifluoromethyl)Pyridine-4-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through Suzuki-Miyaura cross-coupling reactions. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, oncology, and inflammation.
• Agrochemical Synthesis: Used to construct pyridine-based herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Development: Serves as a building block for creating novel ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors for OLEDs and photovoltaic cells.
• Chemical Biology Probes: Facilitates the synthesis of labeled compounds and molecular probes for biochemical and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs serving the life sciences sector.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Pyridine-4-Boronic Acid Pinacol Ester
CAS No.	2121515-21-5
Molecular Formula	C₁₂H₁₄BClF₃NO₂
Molecular Weight	305.50 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloro-5-(trifluoromethyl)pyridine; 2-Chloro-5-trifluoromethylpyridine-4-boronic acid pinacol ester; 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine; 4-Boronic acid, 2-chloro-5-(trifluoromethyl)pyridine-, pinacol ester; CAS 2121515-21-5; 2-Chloro-5-(trifluoromethyl)-4-pyridineboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-(Trifluoromethyl)Pyridine-4-Boronic Acid Pinacol Ester undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive cross-coupling reactions. Our quality assurance protocol includes multiple orthogonal methods to verify identity, purity, and stability. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic confirmation (NMR) are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.