Description

2-Fluoro-3-Methoxypyridine-4-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific fluorinated pyridine motifs.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, ligands for catalysts, and liquid crystals.
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester functionality makes it a stable and highly reactive partner in palladium-catalyzed carbon-carbon bond formation.
• Chemical Biology & Medicinal Chemistry: Employed in the design and synthesis of molecular probes, diagnostic agents, and tool compounds for biological target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	2-Fluoro-3-Methoxypyridine-4-Boronic Acid Pinacol Ester
CAS No.	2121513-86-6
Molecular Formula	C₁₂H₁₇BFNO₃
Molecular Weight	253.08 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-(3-methoxy-2-fluoropyridin-4-yl)-1,3,2-dioxaborolane; 2-(2-Fluoro-3-methoxypyridin-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3-Methoxy-2-fluoro-4-pyridinyl)boronic acid pinacol ester; 2-Fluoro-3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-3-methoxypyridine; Pinacol (2-fluoro-3-methoxypyridin-4-yl)boronate; Boronic acid, B-(2-fluoro-3-methoxy-4-pyridinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Methoxypyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with full analytical data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.