Description

2-Fluoro-3-Isopropoxypyridine-5-Boronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This advanced intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated and heterocyclic scaffolds in drug discovery programs, particularly for kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that leverage the unique properties of the fluoropyridine moiety.
• Material Science Research: Serves as a precursor for synthesizing organic electronic materials, such as ligands for OLEDs and charge-transport molecules.
• Chemical Biology & Probe Development: Facilitates the creation of tagged molecules and bioconjugates for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical component for CROs and CDMOs offering bespoke chemical synthesis services to global clients.
• Academic Research: Enables methodological studies in cross-coupling chemistry and the exploration of new reaction pathways in university and institutional labs.

Basic Information

Product Name	2-Fluoro-3-Isopropoxypyridine-5-Boronic Acid Pinacol Ester
CAS No.	2121513-27-5
Molecular Formula	C14H21BFNO3
Molecular Weight	281.13 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-3-isopropoxypyridine; 2-Fluoro-3-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (2-Fluoro-3-isopropoxypyridin-5-yl)boronic acid pinacol ester; 2-Fluoro-3-(propan-2-yloxy)pyridine-5-boronic acid pinacol ester; Boronic acid, B-(2-fluoro-3-isopropoxy-5-pyridinyl)-, 1,1-dimethylethyl ester; 2121513-27-5; CAS 2121513-27-5
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Isopropoxypyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, critical for sensitive coupling reactions. We employ advanced analytical techniques including NMR, HPLC, and GC-MS for comprehensive characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.