Description

2-Fluoro-5-Methoxypyridine-3-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and agrochemical research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated and methoxy-substituted pyridine cores found in active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and CNS-targeting drugs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine and pyridine motifs enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for creating functionalized organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) with tailored electronic properties.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the 2-fluoro-5-methoxypyridin-3-yl fragment into complex molecules.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and labeled compounds for studying biological processes and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales.

Basic Information

Product Name	2-Fluoro-5-Methoxypyridine-3-Boronic Acid Pinacol Ester
CAS No.	2121512-59-0
Molecular Formula	C₁₂H₁₇BFNO₃
Molecular Weight	253.08 g/mol
Synonyms	(2-Fluoro-5-methoxypyridin-3-yl)boronic acid pinacol ester; 2-Fluoro-5-methoxy-3-pyridineboronic acid pinacol ester; 3-Borono-2-fluoro-5-methoxypyridine pinacol ester; 5-Methoxy-2-fluoropyridine-3-boronic acid pinacol ester; Pinacol (2-fluoro-5-methoxypyridin-3-yl)boronate; 2-Fluoro-5-methoxypyridine-3-boronic acid, pinacol cyclic ester; 2121512-59-0
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Methoxypyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards required for pharmaceutical R&D and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.