Description

Brd4-In-1 Fl-411 is a potent and selective small molecule inhibitor targeting the Bromodomain and Extra-Terminal (BET) family protein BRD4. This high-purity compound is a critical research tool for investigating epigenetic regulation, gene transcription, and their roles in oncology and inflammatory diseases. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on developing novel targeted therapies.

Application

• Biomedical Research: A key reagent for studying BET protein biology, chromatin remodeling, and transcriptional regulation in cellular models.
• Oncology Drug Discovery: Used in target validation, high-throughput screening, and mechanism-of-action studies for cancers where BRD4 is implicated (e.g., leukemia, solid tumors).
• Inflammation & Immunology Research: Applied in research models to explore the role of BRD4 in regulating inflammatory gene expression and immune cell function.
• Chemical Biology & Proteomics: Serves as a chemical probe to elucidate protein-protein interactions and downstream signaling pathways involving BET proteins.
• Preclinical Development: Supports in vitro and in vivo pharmacokinetic/pharmacodynamic (PK/PD) studies for candidate optimization.

Basic Information

Product Name	Brd4-In-1 Fl-411
CAS No.	2118944-88-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	BRD4-IN-1; BRD4 Inhibitor FL-411; FL 411; FL-411; BRD4-IN-1 (FL-411); (S)-BRD4-IN-1; BRD4 inhibitor compound FL411; 2118944-88-8; BRD4 Inhibitor (FL-411); BRD4 chemical probe FL-411
EINECS	Contact for details

Quality Control

Our Brd4-In-1 Fl-411 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.