Description

Cdk9-Protac CAS NO 2118356-96-8 is a potent and selective proteolysis-targeting chimera (PROTAC) molecule designed to induce the degradation of Cyclin-dependent kinase 9 (CDK9). This compound matters as a cutting-edge chemical probe and research tool for investigating CDK9's role in transcription regulation, cell cycle control, and disease pathways, particularly in oncology. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on targeted protein degradation (TPD) strategies, cancer biology, and the development of novel therapeutic modalities.

Application

• Targeted Protein Degradation Research: Serves as a key chemical tool for validating the PROTAC mechanism and studying CDK9 biology in cellular and in vivo models.
• Oncology and Cancer Biology Studies: Used to investigate the therapeutic potential of CDK9 degradation in various cancer cell lines, including those dependent on transcriptional addiction (e.g., MYC-driven cancers).
• Drug Discovery & Preclinical Development: Acts as a lead compound or reference standard for designing and optimizing next-generation CDK9 degraders.
• Transcriptional Regulation Analysis: Enables research into the effects of rapid CDK9 removal on RNA polymerase II phosphorylation and gene expression profiles.
• Chemical Biology & Proteomics: Utilized in mechanistic studies to understand ternary complex formation, ubiquitin-proteasome system engagement, and kinome-wide selectivity.
• Virology Research: Applied in studies exploring host dependency factors, such as CDK9, for viral replication (e.g., HIV).

Basic Information

Product Name	Cdk9-Protac
CAS No.	2118356-96-8
Molecular Formula	C₄₀H₄₇ClN₈O₇
Molecular Weight	763.31 g/mol
Synonyms	THAL-SNS-032; CDK9 degrader; PROTAC CDK9 Degrader-1; (S,R,S)-AHPC-CDK9 ligand; CDK9-PROTAC; (S,R,S)-AHPC-MeTrazine-CDK9 ligand; BMS Analog for CDK9 Degradation; CDK9 Targeting PROTAC
EINECS	Contact for details

Quality Control

Our Cdk9-Protac is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive biological research. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and potency is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. This compound is intended for research use only in a laboratory setting.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.