Description

(+)-Jq1 Pa CAS NO 2115701-93-2 is a high-purity, enantiomerically pure small molecule inhibitor of the bromodomain and extra-terminal (BET) family of proteins. This compound is a critical research tool for investigating epigenetic regulation and transcriptional control in cellular pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, immunology, and inflammatory disease research.

Application

• Biomedical Research: A potent and selective chemical probe for studying BET bromodomain function in epigenetic mechanisms.
• Drug Discovery & Development: Used in target validation, high-throughput screening, and as a lead compound for developing novel therapeutics.
• Oncology Research: Investigation of its role in modulating gene expression in various cancer cell lines and animal models.
• Inflammation & Immunology Studies: Research into the regulation of inflammatory cytokine production and immune cell function.
• Chemical Biology: Tool compound for understanding protein-protein interactions and transcriptional complexes.
• Preclinical Studies: Evaluation of pharmacokinetics, pharmacodynamics, and efficacy in disease models.

Basic Information

Product Name	(+)-Jq1 Pa
CAS No.	2115701-93-2
Molecular Formula	C23H22ClN3O3S
Molecular Weight	455.96 g/mol
Synonyms	(+)-JQ1 PA; (R)-JQ1 PA; (R)-JQ1-(+)-PA; JQ1 PA, (+)-; Thienotriazolodiazepine BET inhibitor (+)-JQ1 PA; BET Bromodomain Inhibitor (+)-JQ1 PA; (R)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our (+)-Jq1 Pa is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral purity. We adhere to rigorous analytical standards including HPLC, NMR, and mass spectrometry to confirm specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.