Description

Protac Abl Binding Moiety 4 is a specialized chemical building block designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound matters as a critical linker component that specifically binds to the Abl kinase, enabling the targeted degradation of disease-relevant proteins for research and therapeutic development. It is essential for pharmaceutical researchers, medicinal chemists, and biotech companies engaged in the discovery of novel targeted protein degradation therapies.

Application

• PROTAC Molecule Synthesis: Serves as a key warhead or binding moiety in the construction of heterobifunctional PROTAC degraders targeting Abl kinases.
• Kinase-Targeted Drug Discovery: Used in research programs focused on developing degraders for conditions where Abl kinase dysregulation plays a role.
• Chemical Biology Probes: Enables the creation of tool compounds to study kinase function and validate degradation as a therapeutic modality.
• Preclinical Pharmaceutical Development: A vital intermediate in the early-stage development of next-generation targeted cancer therapies and other diseases.
• Academic Research: Supports fundamental studies in ubiquitin-proteasome system (UPS) biology and targeted protein degradation mechanisms.

Basic Information

Product Name	Protac Abl Binding Moiety 4
CAS No.	2112837-79-1
Molecular Formula	C23H23ClN6O2
Molecular Weight	450.92 g/mol
Synonyms	PROTAC ABL Binding Moiety 4; 2112837-79-1; N-(3-((2-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-7-yl)amino)propyl)acrylamide; Abl Kinase Ligand for PROTAC; Abl-targeting PROTAC Linker; PROTAC Abl Ligand 4; Degrader Building Block for Abl
EINECS	Contact for details

Quality Control

Our Protac Abl Binding Moiety 4 is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry. Certificates of Analysis (COA) are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.