Description

Stat5-In-2 is a potent and selective small-molecule inhibitor of the Signal Transducer and Activator of Transcription 5 (STAT5) signaling pathway. This compound matters for researchers and developers targeting oncogenic pathways, as aberrant STAT5 activation is implicated in various hematological malignancies and solid tumors. Professionals in pharmaceutical R&D, academic research, and biotechnology need it for investigating STAT5's role in disease and developing novel therapeutic strategies. The product is supplied under the identifier CAS NO 2111834-61-6.

Application

• Biomedical Research: Used as a critical tool compound for studying the STAT5 signaling pathway in cellular and biochemical assays.
• Oncology Drug Discovery: Serves as a lead compound or reference inhibitor in screens for developing new anti-cancer therapeutics targeting STAT5-dependent cancers.
• Mechanistic Studies: Enables the investigation of STAT5's function in cell proliferation, differentiation, and apoptosis in various disease models.
• Preclinical Development: Utilized in in vitro and in vivo studies to validate STAT5 as a therapeutic target and assess efficacy.
• Chemical Biology: Acts as a molecular probe to elucidate protein-protein interactions and downstream effects of STAT5 inhibition.

Basic Information

Product Name	Stat5-In-2
CAS No.	2111834-61-6
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	STAT5 Inhibitor 2; STAT5-IN-2; 2-[(4-Oxo-3-phenethyl-3,4-dihydrophthalazin-1-yl)thio]-N-(pyridin-3-yl)acetamide; N-(3-Pyridinyl)-2-[(3-phenethyl-4-oxo-1(4H)-phthalazinyl)thio]acetamide; AC-4-130; STAT5 signaling pathway inhibitor
EINECS	Contact for details

Quality Control

Our Stat5-In-2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.