Description

Glutaminyl Cyclase Inhibitor 1 is a potent and selective small molecule inhibitor of the glutaminyl cyclase (QC) enzyme, a key target in neurodegenerative and inflammatory research. This compound is critical for investigating the role of QC in the formation of pathological pyroglutamate-modified proteins, such as amyloid-β (Aβ) in Alzheimer's disease. It is an essential research tool for pharmaceutical R&D, academic institutions, and biotechnology companies focused on developing novel therapeutics for neurodegenerative disorders and chronic inflammation.

Application

• Neurodegenerative Disease Research: A key pharmacological tool for studying the pathogenesis of Alzheimer's disease, Parkinson's disease, and other tauopathies by inhibiting the formation of neurotoxic pyroglutamate-modified amyloid peptides.
• Inflammation and Immunology Studies: Used to investigate the role of QC in the modulation of chemokines (e.g., CCL2, CCL7) and its impact on chronic inflammatory conditions, including atherosclerosis and rheumatoid arthritis.
• Drug Discovery & Preclinical Development: Serves as a reference standard and lead compound in high-throughput screening (HTS) campaigns and medicinal chemistry programs aimed at developing next-generation QC inhibitors.
• Biochemical Assay Development: Employed as a critical control in enzymatic activity assays (FRET-based, fluorescence polarization) to validate assay performance and for inhibitor potency (IC50) determination.
• In Vitro and In Vivo Model Validation: Used to establish proof-of-concept in cellular models (e.g., neuronal cell lines, microglia) and transgenic animal models of disease to elucidate QC's therapeutic potential.

Basic Information

Product Name	Glutaminyl Cyclase Inhibitor 1
CAS No.	2110449-60-8
Molecular Formula	C₂₀H₂₀F₃N₅O₃
Molecular Weight	435.40 g/mol
Synonyms	QC Inhibitor 1; Glutaminyl Peptide Cyclotransferase Inhibitor; PQ529; 1-(3-Carboxy-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)-4-(4-fluorophenyl)piperazine-2-carboxylic acid; 4-{4-[(4-Fluorophenyl)carbonyl]-1-piperazinyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-3-carboxylic acid (alternative IUPAC); QCi; Glutaminyl Cyclase (QC) Inhibitor.
EINECS	Contact for details

Quality Control

Our Glutaminyl Cyclase Inhibitor 1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and Mass Spectrometry. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the rigorous demands of pharmaceutical R&D and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.